Pitt supports One Campaign, an organization aimed at combating AIDS and poverty in the developing world. He narrated the 2005 PBS public television series Rx for Survival: A Global Health Challenge, which discusses current global health issues. The following year Pitt and Jolie flew to Haiti, where they visited a school supported by Yéle Haïti, a charity founded by Haitian-born hip hop musician Wyclef Jean. In May 2007, Pitt and Jolie donated $1 million to three organizations in Chad and Sudan dedicated to those affected by the crisis in the Darfur region. Along with Clooney, Damon, Don Cheadle, David Pressman, and Jerry Weintraub, Pitt is one of the founders of Not On Our Watch, an organization that focuses global attention on stopping "mass atrocities".
On November 22, 2001, Pitt made a guest appearance in the eighth season of the television series Friends, playing a man with a grudge against Rachel Green, played by Jennifer Aniston, to whom Pitt was married at the time. For this performance he was nominated for an Emmy Award in the category of Outstanding Guest Actor in a Comedy Series. In December 2001, Pitt played Rusty Ryan in the heist film Ocean's Eleven, a remake of the 1960 Rat Pack original. He joined an ensemble cast including George Clooney, Matt Damon, Andy García, and Julia Roberts. Well received by critics, Ocean's Eleven was highly successful at the box office, earning $450 million worldwide. Pitt appeared in two episodes of MTV's reality series Jackass in February 2002, first running through the streets of Los Angeles with several cast members in gorilla suits, and participating in his own staged abduction in another episode. In the same year, Pitt had a cameo role in George Clooney's directorial debut Confessions of a Dangerous Mind. He took on his first voice-acting roles in 2003, speaking as the titular character of the DreamWorks animated film Sinbad: Legend of the Seven Seas and playing Boomhauer's brother, Patch, in an episode of the animated television series King of the Hill.
More InfoPitt was cast as an Irish Gypsy boxer with a barely intelligible accent in Guy Ritchie's 2000 gangster film Snatch. Several reviewers were critical of Snatch; however, most praised Pitt. Mick LaSalle of the San Francisco Chronicle said Pitt was "ideally cast as an Irishman whose accent is so thick even Brits can't understand him", going on to say that, before Snatch, Pitt had been "shackled by roles that called for brooding introspection, but recently he has found his calling in black comic outrageousness and flashy extroversion;" while Amy Taubin of The Village Voice claimed that "Pitt gets maximum comic mileage out of a one-joke role". The following year Pitt starred opposite Julia Roberts in the romantic comedy The Mexican, a film that garnered a range of reviews but enjoyed box office success. Pitt's next role, in 2001's $143 million-grossing Cold War thriller Spy Game, was as Tom Bishop, an operative of the CIA's Special Activities Division, mentored by Robert Redford's character. Mark Holcomb of Salon.com enjoyed the film, although he noted that neither Pitt nor Redford provided "much of an emotional connection for the audience".
More InfoFor his next film, Pitt starred opposite Cate Blanchett in Alejandro González Iñárritu's multi-narrative drama Babel (2006). Pitt's performance was critically well-received, and the Seattle Post-Intelligencer said that he was credible and gave the film visibility. Pitt later said he regarded taking the part as one of the best decisions of his career. The film was screened at a special presentation at the 2006 Cannes Film Festival and was later featured at the 2006 Toronto International Film Festival. Babel received seven Academy and Golden Globe award nominations, winning the Best Drama Golden Globe, and earned Pitt a nomination for the Best Supporting Actor Golden Globe. That same year, Pitt's company Plan B Entertainment produced The Departed, which won the Academy Award for Best Picture. Pitt was credited on-screen as a producer; however, only Graham King was ruled eligible for the Oscar win.
More InfoReprising his role as Rusty Ryan in a third picture, Pitt starred in 2007's Ocean's Thirteen. While less lucrative than the first two films, this sequel earned $311 million at the international box office. Pitt's next film role was as American outlaw Jesse James in the 2007 Western drama The Assassination of Jesse James by the Coward Robert Ford, adapted from Ron Hansen's 1983 novel of the same name. Directed by Andrew Dominik and produced by Pitt's company Plan B Entertainment, the film premiered at the 2007 Venice Film Festival, with Pitt playing a "scary and charismatic" role, according to Lewis Beale of Film Journal International, and earning Pitt the Volpi Cup award for Best Actor at the 64th Venice International Film Festival. He eventually collected the award one year later at the 2008 festival. As of January 2019, it was his own favorite of his films.
More InfoPitt's next leading role came in 2009 with the Quentin Tarantino-directed war film Inglourious Basterds, which premiered at the 2009 Cannes Film Festival. Pitt played Lieutenant Aldo Raine, an American resistance fighter battling Nazis in German-occupied France. The film was a box office hit, taking $311 million worldwide, and garnered generally favorable reviews. The film received multiple awards and nominations, including eight Academy Award nominations and seven MTV Movie Award nominations, including Best Male Performance for Pitt. He next voiced the superhero character Metro Man in the 2010 animated feature Megamind. Pitt produced and appeared in Terrence Malick's experimental drama The Tree of Life, co-starring Sean Penn, which won the Palme d'Or at the 2011 Cannes Film Festival. In a performance that attracted strong praise, he portrayed the Oakland Athletics general manager Billy Beane in the drama Moneyball, which is based on the 2003 book of the same name written by Michael Lewis. Moneyball received six Academy Award nominations including Best Picture and Best Actor for Pitt.
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