Moore became a special contributor to the CNN Freedom Project and traveled to Nepal to meet with 2010 CNN Hero of the Year Anuradha Koirala and her organization, Maiti Nepal, which has rescued more than 12,000 stolen Nepalese children from sex trafficking since 1993. Moore was the narrator and anchor of CNN's documentary on child trafficking, called Nepal's Stolen Children, which aired on June 26, 2011. In the documentary, Moore talked to Nepal’s prime minister, Jhalanath Khanal and young girls who were forced into prostitution before being saved by a Nepalese nonprofit.
In 2010, Moore took on the role of a daughter helping her father deal with age-related health problems in the dramedy Happy Tears, opposite Parker Posey and Rip Torn, and starred as the matriarch of a family moving into a suburban neighborhood in the comedy The Joneses, with David Duchovny. The latter film was largely highlighted upon its theatrical release, with critics concluding that it "benefits from its timely satire of consumer culture — as well as a pair of strong performances" from Duchovny and Moore. In Bunraku (2010), a film Moore described as a "big action adventure," she played a courtesan and a femme fatale with a secret past.Moore portrayed a chief risk management officer at a large Wall Street investment bank during the initial stages of the financial crisis of 2007–08 in the critically acclaimed corporate drama Margin Call (2011), where she was part of an ensemble cast that included Kevin Spacey, Simon Baker, and Paul Bettany. The cast garnered nominations for the "Best Ensemble" award from the Gotham Awards, the Phoenix Film Critics Society and the Central Ohio Film Critics Association. Also in 2011, Moore received a Directors Guild of America Award nomination for Outstanding Directing – Miniseries or TV Film for her work as a director in a segment of the 2011 Lifetime anthology film Five, and starred opposite Ellen Barkin, Ellen Burstyn and George Kennedy in Sam Levinson's black comedy Another Happy Day, which premiered at the Sundance Film Festival.
More InfoMoore had a lead role as a grieving and tormented novelist in the mystery thriller Half Light (2006), then took on the role of a driven police officer investigating a serial killer in the psychological thriller Mr. Brooks (2007), with Kevin Costner. The film received mixed reviews and grossed $48.1 million worldwide. Rolling Stone wrote that "the cop on the case, played by Demi Moore with a striking directness that deserved better than being saddled with an absurd back story as an heiress with a fortune-hunting husband."
More InfoMoore appeared as the mother of Miley Cyrus' character in the romantic drama film LOL (2012). She played a similar mother role in her next film, the likewise coming-of-age dramedy Very Good Girls (2013), which co-starred Dakota Fanning and Elizabeth Olsen. Her part as an old flame of a quick-draw killer in the Western drama Forsaken (2015), with Donald Sutherland and Kiefer Sutherland, was followed by the role of the daughter of a retired high school teacher in the road comedy Wild Oats, which premiered on Lifetime in August 2016, and in a limited release the following month.
More InfoMoore was off screen for three years before re-emerging in the arthouse psychological drama Passion of Mind (2000), the first English-language film from Belgian director Alain Berliner. Her performance as a woman with multiple personality disorder was well received, but the film itself garnered mixed reviews and was deemed "naggingly slow" by some critics. Moore then resumed her self-imposed career hiatus and continued to turn down film offers. Producer Irwin Winkler said in 2001, "I had a project about a year and a half ago, and we made an inquiry about her—a real good commercial picture. She wasn't interested."
More InfoMoore has supported numerous charities, including All Day Foundation, American Foundation for AIDS Research, Artists for Peace and Justice, Coalition to Abolish Slavery and Trafficking, Declare Yourself, Free The Slaves, Healthy Child Healthy World, Raising Malawi, The Art of Elysium and UNICEF. In 2010, Moore defeated Kevin Bacon to win $250,000 in the Pepsi Refresh Celebrity Challenge. She chose to support the organization GEMS: Girls Educational & Mentoring Services, a nonprofit group which aims to empower young women who have been the victims of commercial sexual exploitation and trafficking. She traveled to Haiti with the Artists for Peace and Justice following the earthquake of 2010. She has also supported Chrysalis, a non-profit organization which offers employment opportunities to the homeless.
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